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Understanding this could help clinicians offer the best treatment options for each patient. David Malkin, co-lead author, Staff Oncologist, Scientist and co-Director of the SickKids Cancer Sequencing KiCS program, said: "As an increasing and diverse number of tumour genome sequences become available, we may be able to define further rearrangement processes that underlie fusion genes and thus unravel the causes of fusion-driven human cancers.

Our goal is to better understand these cancers in an attempt to improve treatment and outcomes.

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Materials provided by Wellcome Trust Sanger Institute. Note: Content may be edited for style and length. Science News. Overpeck, Judy R. Allen, Patricia M. Anderson, Julio L. Betancourt, Heather A. Binney, Simon Brewer, Mark B. Bush, Brian M. Edwards, William D. Gosling, Simon Haberle, Sara C.


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Past and future global transformation of terrestrial ecosystems under climate change. Science , ; : DOI: ScienceDaily, 30 August Wellcome Trust Sanger Institute. Children's bone cancers could remain hidden for years before diagnosis: Complex genetic rearrangements found which could inform treatment. Retrieved July 9, from www. Whole genome sequencing of tumours revealed mutations which are targetable by existing drugs used to treat Probably not.

Children's bone cancers could remain hidden for years before diagnosis

Of the 6. Instead, the rapid increase in people with A. Which is not to say that A. Scientists often study twins to examine whether certain behaviors and traits are inborn. They do this by comparing identical twins who share almost percent of the same genes with fraternal twins who share about half their genes.

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If a disorder has a genetic basis, then identical twins will be more likely to share it than fraternal twins. In , researchers at Michigan State University analyzed 22 different studies of twins and found that the traits of hyperactivity and inattentiveness were highly inheritable. Numerous brain-imaging studies have also shown distinct differences between the brains of people given diagnoses of A.

None of that research yet translates into an objective diagnostic approach, however. Before I received my diagnosis, I spent multiple sessions with a psychologist who interviewed me and my husband, took a health history from my doctor and administered several intelligence tests. Most children are given the diagnosis on the basis of a short visit with their pediatrician. In fact, the diagnosis can be as simple as prescribing Ritalin to a child and telling the parents to see if it helps improve their school performance. This lack of rigor leaves room for plenty of diagnoses that are based on something other than biology.

Case in point: The beginning of A.


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  7. The incorporation of A. For the first time, the diagnosis came with an upside — access to tutors, for instance, and time allowances on standardized tests. By the late s, as more parents and teachers became aware that A. Stephen Hinshaw, a professor of psychology at University of California, Berkeley, has found another telling correlation. In , In California, that number was 6. This disparity between the two states is representative of big differences, generally speaking, in the rates of diagnosis between the South and West.

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    Hinshaw, as well as sociologists like Rafalovich and Peter Conrad of Brandeis University, argues that such numbers are evidence of sociological influences on the rise in A. In trying to narrow down what those influences might be, Hinshaw evaluated differences between diagnostic tools, types of health insurance, cultural values and public perceptions of mental illness.

    Nothing seemed to explain the difference — until he looked at educational policies. Bush, was the first federal effort to link school financing to standardized-test performance. But various states had been slowly rolling out similar policies for the last three decades. North Carolina was one of the first to adopt such a program; California was one of the last.

    Different for girls: understanding autism | Life and style | The Guardian

    The correlations between the implementation of these laws and the rates of A. When Hinshaw compared the rollout of these school policies with incidences of A. Nationwide, the rates of A.