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Analysis and Assessment

The date of our most recent search was 29 November We included randomised controlled trials that compared psychosocial interventions in adults aged 18 years or over undergoing cancer treatment with palliative intent for incurable cancer versus usual care or other controls.

Psychosocial interventions were defined as various kinds of interventions provided to influence or change cognitions, emotions, behaviours, social interactions, or a combination of these. Psychosocial interventions of interest to this review had to involve at least two interactions between the patient and the care provider in which the care provider gave the patient personal feedback concerning changes sought by these interventions.

We included trials that reported fatigue as an outcome of interest. We used standard methodological procedures expected by Cochrane. Two review authors independently considered trials for inclusion in the review , assessed risk of bias , and extracted data , including information on adverse events. We identified 14 studies 16 reports that met inclusion criteria for this review and involved randomised participants in total.

Most of these studies included a mixed sample of participants; we obtained data for the subset of interest for this review diagnosis of incurable cancer and receiving cancer treatment from the study investigators of 12 studies, for which we included participants in the subset meta-analysis for fatigue post intervention.


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Researchers investigated a broad range of psychosocial interventions with different intervention aims and durations. We identified sources of potential bias , including lack of description of methods of blinding and allocation concealment and inclusion of small study populations. Findings from our meta-analysis do not support the effectiveness of psychosocial interventions for reducing fatigue post intervention standardised mean difference SMD First follow-up findings on fatigue suggested benefit for participants assigned to the psychosocial intervention compared with control SMD Results for our secondary outcomes revealed very low-quality evidence for the efficacy of psychosocial interventions in improving physical functioning post intervention SMD 0.

These findings were not sustained at first follow-up SMD 0. Findings do not support the effectiveness of psychosocial interventions for improving social functioning mean difference MD 4. Only three studies evaluated adverse events.


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These studies found no difference between the number of adverse events among participants in the intervention versus control group. Using GRADE, we considered the overall quality of evidence for our primary and secondary outcomes to be very low. Craig Eds. Hurst, N. Measuring health-related quality of life in rheumatoid arthritis: Validity, responsiveness, and reliability of EuroQol EQ-5D. Jansen, A.

Quality of life measurement in patients with transfusion-dependent myelodysplastic syndromes. Kantarjian, H. Decitabine improves patient outcomes in myelodysplastic syndromes: Results of a phase III randomized study. Kornblith, A. Impact of azacytidine on the quality of life of patients with myelodysplastic syndrome treated in a randomized phase III trial: A Cancer and Leukemia Group B study.

Kurtin, S. Risk analysis in the treatment of hematological malignancies in the elderly. Latsko, J. Uncertainty and distress associated with myelodysplastic syndromes MDS. Lindquist, K. Health care utilization and mortality among elderly patients with myelodysplastic syndromes. Longo, C.

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Description of an Australian model for end-of-life care in patients with hematologic malignancies.

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Fatigue in patients with cancer. Analysis and assessment.

Ream, E. Richards, T. Ritchie, E. Management of myelodysplastic syndromes in the geriatric patient. The last chapter synthesizes the findings of the consecutive studies, and the appendix contains the Fatigue Assessment Questionnaire. This book is a must for reseachers, oncology nurses, physicians and psychologists who deal with this relevant aspect of quality of life in cancer patients. JavaScript is currently disabled, this site works much better if you enable JavaScript in your browser.

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